On the question of the TIL sub-groups infiltration level in CRC, the study found that the levels of infiltration from high to low were M2 macrophages, followed by resting CD4+ memory T cells, M0 macrophages, CD8 + T cells, activated CD4+ memory T cells, T cell follicular helper, and regulatory T cells in three TCGA cohorts. This evidence concerns the gene CD4 and colorectal carcinoma.