Furthermore, we noticed that the function and application value of glycans and glycosylation has gradually emerged in colon cancer, especially Programmed Death Ligand 1 (PD-L1, CD274) which is highly glycosylated, and the role of glycosylation in PD-L1 stability is regulated by the IL-6/Jak1 signaling, by affecting PD-L1 glycosylation. Here, CD274 is linked to malignant colon neoplasm.