Previously, we demonstrated that CUX1 activates p16INK4a‐dependent cellular senescence in human ECs via binding to the atherosclerosis‐associated fSNP rs1537371, with the risk allele A binding more CUX1 than the non‐risk allele C (Jiang et al., 2022), which reveals a mechanism underlying the contribution of the atherosclerosis‐associated fSNP rs1537371 to the susceptibility of this disease. Here, CDKN2A is linked to atherosclerosis.