Previously, we identified that homeodomain transcription factor CUX1, as one of the six proteins in a complex, activates p16INK4a‐dependent cellular senescence via its specific binding to the atherosclerosis‐associated fSNP rs1537371 on the CDKN2A/B locus in human arterial ECs (Jiang et al., 2022). This evidence concerns the gene CUX1 and atherosclerosis.