CD4 and neoplasm: IL‐6 is a major immunosuppressive cytokine within the TME that leads to immunoediting of the TIME,54 which can decrease the activity of anti‐tumor immune cells (dendritic cells, cytotoxic T‐cells)63, 64, 65 and promote the accumulation of pro‐tumor immune cells (tumor‐associated macrophages [TAM], myeloid‐derived suppressor cells [MDSCs], CD4+ T‐cells, and fibroblasts).66