Herein,we postulate that using a modified graphene oxide (GO) carrier todeliver small interfering RNA (siRNA) CD47 (CD47_siRNA) in AML, A549lung, and HepG2 liver cancer cells in co-culture in vitro will silence CD47 and flag cancer cells for CRT-mediated phagocytosis.Results showed a high knockdown efficiency of CD47 and a significantincrease in CRT levels simultaneously by using GO formulation as carriersin all used cancer cell lines. The gene discussed is CD47; the disease is acute myeloid leukemia.