Toexplore the subsequent effect of CD47 downregulation on CRTlevels and tumor cell elimination by macrophages, the knockdown ofCD47 was carried out by the delivery of CD47_siRNA to AML, lung, andliver tumor cells in vitro using different carrierswith different modification strategies, namely, 2D flakes of GO modifiedwith PEG and dendrimers (GO-PEG-PAMAM), 1D nanotubes functionalizedwith water-soluble polymers (BNP: BNNT-polymer), and “0D”nanoparticles using ionizable lipids (LNPs). Here, CD47 is linked to neoplasm.