The effect of the knockdownof CD47 on CRT levels and phagocytosis in cancer cells was investigated.Small-GO-PEG-PAMAM as nanocarriers resulted in a high CD47 knockdownefficiency and significant increase in CRT level in all cancer cells.The presence of CRT on cancer cells was required for phagocytosisby macrophages in co-culture. Here, CALR is linked to cancer.