According to the data from TCGA PanCancer Atlas Studies, non-small-cell lung cancer (NSCLC), CRC, and pancreatic cancer [particularly, pancreatic duct adenocarcinoma (PDAC)] are the three most common cancers associated with KRAS mutations, with incidence of ∼30%, ∼42%, and ∼80%, respectively [10–12]. Here, KRAS is linked to familial pancreatic carcinoma.