ACP5 and diabetes mellitus: The osteoclast formation indicated by TRAP-positive staining was significantly increased in D-control compared with W-control, whereas the osteoclast formation decreased significantly (p < 0.05) in both the AdipoRon-treated diabetic mice (Diabetes + AdipoRon, D + AdipoRon) and the normal mice (Wild + AdipoRon, W + AdipoRon) (Figures 2B,C).