Taking together, our results confirmed that AdipoRon may improve the osseointegration of dental implants in mice with T2DM for 2 weeks through promoting osteogenesis and inhibiting bone resorption mediated by the regulation of bone formation-related markers such as Rankl, BMP2, OPG, OPN, and Runx2. Here, BMP2 is linked to type 2 diabetes mellitus.