ERBB2 and breast carcinoma: To evaluate the potential involvement of NAE1 in breast cancer, we also analyzed the expression of NAE1 gene from published microarray data sets and found that NAE1 expression was higher in HER2+ human breast cancer (Figure 6A) 30 and the overexpression of NAE1 mRNA had a worse overall survival in all breast cancer (Figure 6B) 31.