We found that addition of NPY significantly upregulated Y1R while inhibiting cisplatin-induced AKI by blocking NF-κB-Mincle-driven renal inflammation including inactivation of F4/80+Mincle+iNOS+ M1 macrophages (Figures 4 f,g and 5e-h, and Figure 7). The gene discussed is CLEC4E; the disease is acute kidney injury.