Consistent with a known role for NF-κB-Mincle signaling in M1 macrophages-mediated AKI as well as in protumoral activities of tumor-associated macrophages 9-11, 45, the present study unraveled that NPY signals through the Y1R to inactivate M1 macrophages and renal necroinflammation by inhibiting NF-κB-Mincle signaling. This evidence concerns the gene NPY and neoplasm.