Furthermore, knocking down M6PR in SRGN-overexpressing ESCC cells, which resulted in a marked decrease in M6PR in cell lysate, CM and exosomes (Figure 6B), abolished the stimulatory effect of both SRGN CM and SRGN Exo on tube formation of HUVECs (Figure 6C-F). This evidence concerns the gene M6PR and esophageal squamous cell carcinoma.