Ma et al. found that Simiao pill restores high fructose-induced hyperuricemia and metabolic syndrome by up-regulating SIRT1 in glomerular of mice with high-fructose, inhibiting NF-κB pathway and the activation of NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome, improving interstitial infiltration of nephritis cells and glomerular injury and reducing urinary albumin level 94. Here, SIRT1 is linked to hyperuricemia.