In contrast, SIRT1 deficiency leads to the decrease in the secretion of thyroid hormone 12, estrogen 13, testosterone14, and pituitary hormone 15, causing disorders of endocrine and metabolic system, thereby developing into obesity 16, diabetes 17, hyperuricemia 18, hyperlipidemia 19, hypertension 20. The gene discussed is SIRT1; the disease is Hypertension.