A recent study showed that lncRNA-00470 decreases the phosphatase and tensin homolog (PTEN) stability by triggering METTL3-mediated m6A modification, thus inhibiting cell autophagy while promoting chemoresistance in chronic myeloid leukemia (CML) 56. The gene discussed is PTEN; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.