A previous study showed that the upregulation of METTL3 induced by lipotoxicity promotes rubicon expression in an m6A-dependent manner, inhibiting autophagy and further suppressing the clearance of lipid droplets (LDs) via lysosomes in nonalcoholic fatty liver disease (NAFLD) 59. The gene discussed is METTL3; the disease is metabolic dysfunction-associated steatotic liver disease.