Gain and loss of function experiments demonstrated that overexpression of BGN in AGS promoted the proliferation (Fig. 2c, 2e), migration (Fig. 2g, 2i), and invasion (Fig. 2i) of GC cells, while knockdown of BGN in HGC27 inhibited the proliferation (Fig. 2d, 2f), migration (Fig. 2h, 2j), and invasion (Fig. 2j) of GC cells. The gene discussed is BGN; the disease is gastric cancer.