YAP1 and dilated cardiomyopathy: Supportive to this notion also comes from studies on the cardiomyocyte-restricted genetic interventions that either activate Mst1 (i.e. Mst1-TG) 19, 21 or suppress YAP or TEAD1 (i.e. YAP- or TEAD1-gene deletion) 23, 24, 51, all result in dilated cardiomyopathy with significant interstitial fibrosis.