Among these findings, upregulated GPD2 in thyroid cancer enhanced the rate of OXPHOS in support of cancer cell growth 25; proliferation of glioma cells was increased due to higher glycolytic rate upon GPD2 activation 26, and anchorage-independent cell growth was inhibited by GPD2 knockdown due to disrupted energy metabolism in liver cancer cells 27. Here, GPD2 is linked to central nervous system cancer.