As this observed change in cell morphology and proliferation potential are common features in the A549 parental/Ctrl (Figure 2G), FAM3C_kd (Figure S5A) and FAM3C_ox (not shown) lung sections, we can conclude that this is an inherent characteristic of the A549 lung cancer cell line independent of the cells' FAM3C expression status. This evidence concerns the gene FAM3C and lung cancer.