In the present study, by coupling mass-spectrometry-based proteomics and biochemical assays in lung cancer cells validated with patient's plasma samples, we identify FAM3C, a secreted interleukin-like EMT inducer (ILEI), is an oncogenic cargo protein encapsulated within TDEs through which cell-cell growth signals are potentially communicated. The gene discussed is FAM3C; the disease is lung carcinoma.