FAM3C expression in the A549 parental and FAM3C_ox tumor nodules appear to be unipolar or perinulcear in these small tightly packed carcinoma cells (Figure 2F upper panels; 1, Figure S5B, red arrows) and as punctate cytoplasmic positivity proximal to the nuclei in the larger spread carcinoma cells (2, Figure S5B, black arrows). Here, FAM3C is linked to neoplasm.