The aetiology of DCM has been related to specific transporters and receptors expressed in the outer mitochondrial membrane (OMM) and inner mitochondrial membrane (IMM), and these proteins, such as TSPO and voltage-dependent calcium channels (VDAC), have become important therapeutic targets in drug development 12, 44, 45. The gene discussed is TSPO; the disease is familial dilated cardiomyopathy.