PDPN and neoplasm: LYVE-1 and podoplanin (specific marker of the lymphatic endothelium, used to distinguish between lymphatic and blood vessels) staining intensity in the primary tumors was greater in mice overexpressing ALKBH5 than in control mice, as was LN metastases and tumor cell infiltration in the popliteal LNs (via H&E staining) (Figure 2D).