ALKBH5 promotes tumor-associated lymphangiogenesis and then LN metastasis, in which ALKBH5 stimulates downstream focal adhesion kinase (FAK)/Src proto-oncogene (Src) signalling and boosts integrin subunit beta 1 (ITGB1) expression by disrupting the YTHDF2 protein-mediated m6A degradation pathway. This evidence concerns the gene PTK2 and neoplasm.