Besides, whether the increased BTN2A1/BTN3A1 activation signals allow Vδ2 T cells to overcome inhibitory cells such as myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs) and regulatory T cells (Tregs) in the TME of NPC remain to be investigated 44. The gene discussed is BTN2A1; the disease is nasopharyngeal carcinoma.