Notably, in both amyloid-β (Aβ) and tau C. elegans models of AD, mitophagy induced by urolithin A was demonstrated to restore memory impairment through mechanisms that dependent on PINK1, Parkinson's disease-related-1 (PDR-1) or DAF-16/FOXO-controlled germline-tumor affecting-1 (DCT-1) 50. Here, MAPT is linked to Alzheimer disease.