On the other hand, in the model of cardiac ischemia/reperfusion injury, receptor-interacting serine/threonine-protein kinase 3 (RIPK3) can inhibit FUNDC1-mediated mitophagy and then promote myocardial cell apoptosis, which proves that phosphorylation is involved in regulating FUNDC1-mediated mitophagy 44. Here, FUNDC1 is linked to myocardial ischemia.