NFE2L2 and non-small cell lung carcinoma: More recently, in a systematic study that aims to determine the redox vulnerability of KEAP1-NRF2-mutant NSCLC, CRISPR-Cas9-based screen for antioxidant enzymes led to the identification of multiple hits involved in the pentose phosphate pathway (PPP), the thioredoxin-dependent antioxidant system, and glutathione reductase, as well as mitochondrial superoxide dismutase 2 (SOD2) 36.