HIF1A and cancer: Furthermore, Zhang et al. demonstrated that NRF2 stimulates cancer cell progression by targeting HIF1α to enhance the expression of several key glycolytic genes including hexokinase 2 (HK2), phosphofructokinase-2/fructose-2,6-bisphosphatase 3 (PFKFB3), pyruvate kinase isozymes M2 (PKM2) and lactate dehydrogenase A (LDHA) 40.