KEAP1 and non-small cell lung carcinoma: In addition, Keap1-deficient KrasG12D mouse lung tumors arising from a bronchiolar cell-of-origin, lack pro-tumorigenic macrophages that are observed in tumors originating from alveolar cells 17, further reinforcing the notion that cells-of-origin influence the pathobiology of KEAP1-mutant NSCLC.