HK2 and Familial prostate cancer: To study the effect of Myc inhibition on glucose metabolism in prostate cancer cells, we first examined the effect of Myc inhibitors on the mRNA expression levels of several genes critically involved in glucose metabolism, including glucose transporter 1 (GLUT1), glutaminase (GLS), hexokinase 2 (HK2), and lactate dehydrogenase A (LDHA).