O-GlcNAcylation not only directly modulates the activity of many oncogenes, such as p53, NFκB, and MYC 11,44,46, but also indirectly affects the self-renewal potential and metastatic ability of tumor cells by altering immune checkpoint molecules and impacting tumor microenvironments 13,15,47,48. This evidence concerns the gene TP53 and neoplasm.