In the following decade, studies on ATAD2 became more comprehensive and in-depth, from the upstream factors regulating ATAD2 protein expression (such as miR-372, lnc PACT-14) to the mechanism of action involved in the occurrence and development of breast cancer, lung adenocarcinoma, liver cancer and other diseases 10-13. The gene discussed is ATAD2; the disease is lung adenocarcinoma.