As expected, female het Gabrg2+/Q390X KI mice did show a larger amplitude power within EEG delta frequency (0.1–4 Hz) than male het Gabrg2+/Q390X KI mice (Fig. 7A) [mV2/Hz, male (n = 13), 0.0014 ± 0.00034 versus female 0.0109 ± 0.0042 (n = 13), t-test P = 0.037], suggesting that NREM sleep difference in delta-frequency power may generate the gender difference in epileptic SWD incidence during sleep in human Dravet syndrome patients. The gene discussed is GABRG2; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.