In addition, in female het Gabrg2+/Q390X KI mice, EEG delta-frequency (0.1–4 Hz) power during NREM sleep was significantly larger than that in male het Gabrg2+/Q390X KI mice, which likely contributes to gender difference in seizure incidence in human Dravet syndrome patients. The gene discussed is GABRG2; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.