GABRG2 and epilepsy: Our recent work has found that artificially induced sleep-like slow-wave oscillations (SWOs) can trigger epileptic seizures in het Gabrg2+/Q390X KI mice by a sleep-related, state-dependent homeostatic synaptic potentiation mechanism.1 In this study, we examined if sleep SWOs themselves in vivo could causally trigger seizures in het Gabrg2+/Q390X KI mice, which might have implication for seizure onset mechanism and sex incidence difference in human epilepsy patients.