SMS can influence the metabolic process and is involved in tumor growth (Guo et al., 2020).Overexpression of ACACA, ME1, ADSL or S100A10 promotes HCC growth, migration or invasion, and is connected with poor prognosis (Jiang et al., 2021; Nakashima et al., 2018; Wang et al., 2016b). The gene discussed is ME1; the disease is hepatocellular carcinoma.