BRCA1 and Li-Fraumeni syndrome: Multiple studies have confirmed that there are noticeable family genetic characteristics in the tumorigenesis of malignant tumors, such as ovarian cancers (BRCA1 and BRCA2 mutations) (Heemskerk-Gerritsen et al., 2022), Li-Fraumeni syndrome (TP53 mutation) (Rocca et al., 2022) and hereditary nonpolyposis colorectal cancer (DNA mismatch repair deficient) (Liotta et al., 2021).