PSMD14 and colorectal cancer: Wang et al. (2018) demonstrated that PSMD14 depletion increased p53 stability, resulting in apoptosis of colorectal cancer (CRC) cells. In esophageal squamous cell carcinoma, knockdown of PSMD14 significantly blocks SNAIL-induced epithelial mesenchymal transition (EMT), thus suppressing tumor cell migration and metastasis (Zhu et al., 2018).