Analysis of a large genomic patient dataset revealed that the SLRPs lumican, fibromodulin and decorin as well as COL1A1 and COL6A1 all correlate with good overall survival in SHH MB patients; suggesting that the presence of this ECM shell in SHH tumours may be a reliable biomarker of good outcome (Fig. 7c, Additional file 2: Fig. S11a and b) [21]. This evidence concerns the gene FMOD and neoplasm.