The increase in VGlut1 levels in PR terminals at the age of 6 months is consistent with higher levels of glutamate release, leading to faster replenishment at the synapse and, thus, a shorter OFF latency and in line with recently published data using another mouse model of AD-like pathology (Tg2576) to assess some features of tauopathy [33]. Here, SLC17A7 is linked to tauopathy.