The 14q32.33 locus comprises the genes KIAA0125 (HGNC: 9834), ADAM6 (HGNC: 8755), LINC00226 (HGNC: 338,004), IGHD (HGNC:5480), IGHG3 (HGNC:5527), and IGHG1 (HGNC:5525); none of these genes has been associated with Mendelian diseases (OMIM) related to genetic dosage (https://search.clinicalgenome.org/kb/gene-dosage/region/ISCA-37477), and there are no regulatory sequences that could modify gene expression in any of the regions of the four CNV; neither of our CNV reported overlap with LCSH regions. This evidence concerns the gene IGHD and hereditary disease.