Under the influence of pulmonary hypoperfusion, the top 20 enriched pathways were cell cycle, DNA replication, RNA transport, microRNAs in cancer, PI3K-Akt signaling pathway, cellular senescence, focal adhesion, progesterone-mediated oocyte maturation, mismatch repair, insulin resistance, ECM-receptor interaction, spliceosome, oocyte meiosis, human papillomavirus infection, Fanconi anemia pathway, pyrimidine metabolism, AGE-RAGE signaling pathway in diabetic complications, one carbon pool by folate, other types of O-glycan biosynthesis, and platelet activation (Fig. 6C, D). Here, AKT1 is linked to human papilloma virus infection.