Yang et al. [50] found in the study of myeloma that hepatocytes increase the secretion of CRP (C-reactive protein) in response to myeloma-derived cytokines, and the binding of CRP to FCGR2 on the surface of myeloma cells activates myeloma cells to promote osteoclastogenesis and bone destruction in vivo. Here, FCGR2A is linked to plasma cell myeloma.