FCGR2B and plasma cell myeloma: Yang et al. [50] found in the study of myeloma that hepatocytes increase the secretion of CRP (C-reactive protein) in response to myeloma-derived cytokines, and the binding of CRP to FCGR2 on the surface of myeloma cells activates myeloma cells to promote osteoclastogenesis and bone destruction in vivo.