TYROBP and FCGR2A were associated with osteonecrosis at different sites in the same pathway, among which the mutation of TYROBP-DAP12 encodes membrane receptor component cells in natural killer cells and myeloid cells, which has been confirmed by Juha Paloneva et al. [46], meaning TYROBP-mediated signaling pathway played an vital role in human bone tissue. The gene discussed is FCGR2A; the disease is osteonecrosis.