ERBB2 and breast neoplasm: In Fig. 5C, SPECT/CT images displayed intense tracer accumulation in the left breast tumor of patient No. 26 with IHC classified HER2 (3 +), with T/B of 4.22, while PET/CT images showed moderate uptake of 18F-FDG in the left breast lesion (T/B = 6.77).