99mTc-HP-Ark2 showed notably enhanced tumor uptake (3.99 ± 0.15%ID/g) at 0.5 h p.i. compared to 99mTc-HP-rk (1.94 ± 0.12 %ID/g, P < 0.0001, n = 4), with no significant difference in other organs except the kidneys. The gene discussed is AURKB; the disease is neoplasm.