Besides, signaling pathways associated with cancer progression, such as pathways in cancer, MAPK signaling pathway, were also enriched in KEGG pathway analysis (Fig. 5B) Gene set enrichment analysis (GSEA) using TCGA STAD data showed integrin was the mainly pathway enriched in high AFAP1L1 expression group (Fig. 5C). Here, AFAP1L1 is linked to cancer.