S1PR2 and cancer: According to GO/KEGG analysis, we can find that central carbon metabolism in cancer, arachidonic acid metabolism, retinol metabolism, primary bile acid biosynthesis, metabolism of xenobiotics by cytochrome P450, xenobiotic metabolic process and other pathways are related, which indicates that the changes of metabolic pathway may play an important role in the occurrence and development of NAFLD-HCC, and S1PR2 may play a certain role in this process, which is consistent with previous studies [36–39].