S1PR2 and Familial prostate cancer: In addition, studies have shown that S1PR2 served as a cancer-promoting gene in papillary thyroid carcinoma cells [30], multiple myeloma [8], chronic granulocytic leukemia [31], bladder cancer, and prostate cancer [32], but served as a cancer-suppressing gene in melanoma [33], glioblastoma [34], and diffuse large B-cell lymphoma [35].