For the carrier of a 1.56 Mb 7p22.3-p22.2 microduplication31 (case SO1: age 35 years, sperm count 0.2 × 106/ejaculate, bitesticular volume 23 ml, FSH 13.7 IU/L; Table 4), retrospective clinical records revealed mild ID, behavioral and cognitive problems, residual schizophrenia, and diagnosis of a joint disorder. The gene discussed is BRD2; the disease is schizophrenia.