To assess regional changes in the substrate (H3K4me3) and product (H3K4me1) of KDM5C at promoter- and enhancer sites, we performed Chromatin Immuno-Precipitation sequencing (ChIP-seq) of H3K4me1, H3K4me3, H3K27me3, and H3K27ac in transplanted Kdm5c-KD and control Lp30 AML cells. The gene discussed is KDM5C; the disease is acute myeloid leukemia.