TRDV1 and neoplasm: Notably, we found TRDV1 and TRDV3, which encode the variable regions of the δ1 and δ3 chains of the γδ T cell receptor (TCR), among the most significantly upregulated loci in B2MMUT tumours (TRDV1, two-sided limma-voom-based regression, FDR-adjusted P = 0.00090, adjusted for tumour type; TRDV3, two-sided limma-voom-based regression, FDR-adjusted P = 0.0015, adjusted for tumour type; Fig. 1d), regardless of the allelic status of the B2M alteration (Extended Data Fig. 1d).