LEP and obesity due to melanocortin 4 receptor deficiency: By using the Iberian pig as translational model for studies on metabolic syndrome, type 2 diabetes and nutrition-associated diseases, a polymorphism of the leptin receptor (LEPR c.1987C > T) has been informed to increase insatiability and obesity (i.e., state that in human medicine is called as leptin resistance)53, and as such, the Iberian pigs would be resistant to leptin-induced lipolysis50.