Between day 0 and 4 from ICU admission, the urine MIF level changed on average from 2694 ± 686 to 2534 ± 893 pg/ml in patients without renal dysfunction, while from 1774 ± 653 to 2658 ± 918 pg/ml in patients with renal dysfunction (Fig. 6B). Here, MIF is linked to Abnormal renal physiology.