MIF and Abnormal renal physiology: The mean daily changes in urine MIF levels were 220 ± 157 pg/ml and − 40 ± 191 pg/ml with and without renal dysfunction, respectively (Fig. 6C), which were not statistically different between the groups even if the urine MIF/creatinine ratios were used for comparison of the groups (0.01 ± 0.04 vs. − 0.01 ± 0.13 pg/μmol/day, respectively).