More than 170 groups of biomarkers have been identified for the assessment of sepsis, including indicators such as PCT, CRP, TNF-α/IL-6, MCP-1, and miRNA6–8, however, different biomarkers play different roles in the pathophysiology of sepsis, and the misuse of certain biomarkers will lead to overdiagnosis and overuse of drugs such as antibiotics9–11. Here, IL6 is linked to Sepsis.