VIM and neoplasm: Furthermore, we demonstrated that the ubiquitin-like domain, located at the N-terminus of the FERM domain, was not only responsible for vimentin binding, but also the sole functional domain for FRMD3’s inhibitory effects on BRCA since mutant FRMD3 with the deletion of the ubiquitin-like domain almost completely lost its tumor suppressor function in BRCA (Fig. 8).