For example, the loss of merlin expression was associated with the development of neurofibromatosis 2-related tumors and merlin functions as a growth negative regulator [36]; likewise, the expression of DAL-1/protein 4.1B was absent in a variety of human tumors, including non-small cell lung cancer and breast cancer, and DAL-1 was able to suppress cell proliferation and EMT and impair cell motility [37]. This evidence concerns the gene EPB41L3 and non-small cell lung carcinoma.