CAV1 and Alzheimer disease: The subsequent protein docking assay provided the possible binding amino sequences of Cav-1 within its transmembrane region39 and those of RgpA within its hemagglutinin domain.40 Gingipain plays a central role in P. gingivalis colonization, inactivation of host defenses and the pathogenesis of AD.9 Therefore, we suggested that gingipain/ RgpA may be the critical molecule that mediates the interaction between P. gingivalis and Cav-1, which should be proved in the future experiments.