METTL3 and diabetes mellitus: In addition, in mice with diabetic foot ulcers (DFUs), adipose-derived mesenchymal stem cells (ADSCs) were found to promote lymphangiogenesis through the METTL3 pathway and improve wound healing by regulating VEGF-C through the METTL3/IGF2BP2-m6A pathway.19 However, how to regulate m6A modifications in DM-BMSCs to enhance impaired function and improve the implant success rate is currently unclear.