Importantly, single-cell analysis of a patient with relapsed/refractory MM confirmed these observations by showing a strong induction of DDIT3 and a concomitant SDC1 reduction, associated with a reduction of the myeloma fraction by >50% after 24 h of NCP26 exposure (Supplementary Fig. S8B–E). The gene discussed is SDC1; the disease is Miyoshi myopathy.