NOXO1 and pulmonary emphysema: Nox subunit NOXO1 (Nox organiser-1) was upregulated in both Nox2−/– animals and wild-type mice with cigarette smoke-induced emphysema, as well as in human COPD, whereas Noxo1−/– mice were protected from cigarette smoke-induced emphysema and PH with right heart hypertrophy.