In the global cohort, a high IPI, advanced disease stage, 2/more extranodal sites, the PS, a low CD4 count, virological suppression, lymphopenia, neutrophilia, a high N:L, a high Treg count, high Treg expression of CD39 and a low MO-Y were all associated with survival on univariate analysis (Table 4). The gene discussed is CD4; the disease is lymphopenia.