The gC mRNA levels in G4m virus were much higher at 72 h and 96 h than those in wild-type and revertant viruses (Fig 8E, left), while gE mRNA levels in G4m virus similar or reduced compared to those in wild-type and revertant viruses (Fig 8E, right), demonstrating that G4 formation in ORF14 indeed inhibits gC expression at the transcriptional level during virus infection. The gene discussed is GC; the disease is viral infectious disease.