MYOC and occult macular dystrophy: In the present study, we evaluated the effects of OMD on the mRNA expression of the ECM, MMPs, and TIMPs in 2D- and 3D-cultured HTM cells, which have been confirmed to be TM cells that increase myocilin gene expression in response to steroids [31,32], in order to elucidate the IOP-lowering mechanism of OMDI that promotes the conventional outflow pathway.