TEAD1 and periodontitis: Shifts in the periodontal microenvironment from G to P may favor the overgrowth of this candidate pathogen, which is frequently associated with Aa + P. gingivalis or F. alocis. Accordingly, the combinations D. pneumosintes + P. gingivalis and D. pneumosintes + F. alocis revealed a strong association with deep periodontal pockets46 and sites with progressing periodontitis,47 respectively.