NFKB1 and necrotizing enterocolitis: Among the genetic alterations associated with NEC, the -94ins/delATTG polymorphism in the promoter region of the NFKB1 gene leads to unregulated activation of the NFKB protein, contributing to the development of NEC, due to an increase in the inherent pro-inflammatory state of the premature intestine15-17,21-23,28.