The use of FZHY improves the condition of “Healthy Qi Deficiency and Evil Qi Excess” in UUO induced RIF rats, which is manifested as the facts that FZHY can reduce kidney tissue inflammation and induce the rebalance of CD4+/CD8+ ratio, and improve the UUO-induced renal fibrosis, providing a better understanding of anti-inflammatory and anti-fibrosis effect of FZHY in RIF. This evidence concerns the gene CD4 and renal fibrosis.