Both mRNA and protein levels of renal fibrosis-related proteins FN, LN, Col-I and Col-III were significantly increased after UUO, but, compared with UUO group, they were significantly decreased after FZHY or AST-120 treatment on the 14th day and on the 21st day (Figs. 4a and 4b). The gene discussed is MLPH; the disease is renal fibrosis.